home >> fact sheets >> Ziprasidone



( This information is not a replacement of full discussions of risks and benefits with your doctor)

Other Names: Zeldox,Geodon.

Principal uses: Ziprasidone is an ‘Atypical Antipsychotic’. It is used in the treatment of schizophrenia, and less commonly in bipolar mood disorder.

Cost:  Fully subsidized on doctor’s prescription.

Dose: The recommended dose is 40mg twice daily to be taken with food. Dose may then be adjusted depending on the response up to a maximum of 80mg twice daily.

How it works: It is thought that the antipsychotic activity of Ziprasidone is mediated through a combination of antagonism (working against) at both serotonin (5HT 2A) and dopamine (D2) receptors. It also affects a number of other receptors which may result in side effects. Serotonin (5HT 1A) agonism (enhancing) may be associated with its anti-anxiety effects.

Possible Side Effects: A wide range of side effects are possible including upset stomach, nausea, constipation, dizziness, restlessness, tremors, sleep disturbance, blurred vision, excessive prolactin secretion, changes in heart rhythm, allergic reactions and rarely serotonin syndrome or malignant neuroleptic syndrome.

Use in Pregnancy: Category C

Animal studies have shown an adverse effect and there are no adequate studies in pregnant women.

There are no adequate and well-controlled studies in pregnant women. Women of child-bearing potential receiving Ziprasidone should therefore be advised to use an appropriate contraception. As human experience is limited, administration of Ziprasidone is not recommended during pregnancy unless the expected benefit to the mother outweighs the potential risk to the fetus.

Use in Breast Feeding: Category L3/L4

No data are available on its transfer into human milk.There are no controlled studies in breastfeeding women; however, the risk of untoward effects to a breastfed infant is possible. Drugs should be given only if the potential benefit justifies the potential risk to the infant. It is advisable not to breastfeed an infant while receiving Ziprasidone

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